A conflict of interest is a situation in which a person has competing loyalties or interests that make it difficult to fulfil his or her duties impartially. Conflict of interest is not categorically improper in itself but requires proper management. A SCOPUS literature search was performed for publications on the efficacy/safety of Phospho-Di-Esterase Inhibitors for treating erectile dysfunction. A categorization tool was used to review and classify the publications as supportive/not-supportive for the discussed active ingredient and reporting or not reporting (...) a COI for that specific drug or for the remaining PDEIs. Multivariable binary logistic regression was performed. In the 419 selected records the prevalence of supportive opinions was higher when a COI for the index label was declared. The CoOpCaT showed good internal consistency, discriminative validity and intra/inter-rater agreement. The strongest predictor for a supportive opinion was the total number of financial COIs for the index label. A mild protective effect of the total number of financial COIs for any competitor label was noted. Financial COIs have frequently been associated with bias, and the measures currently adopted to restrain it lack effectiveness. Some evidence for monitoring and/or compensating this bias is reported here, but the ultimate solution remains distant. (shrink)

In the “Sala dei Mesi” of Palazzo Schifanoia the months and the zodiacal constellations go from right to left, while the decans (three for every sign) go in the opposite direction. This problem was not clarified by Aby Warburg in his well-known essay Italian Art and International Astrology in the Palazzo Schifanoia of Ferrara (1912). The purpose of this paper is to investigate the reasons of this double direction.

Nel processo di digitalizzazione dei testi sembrano emergere somiglianze e analogie con quegli anni del medioevo durante i quali si assiste all'incontro fra la tradizione latina occidentale e il patrimonio culturale di provenienza greca e araba. Due mondi che traducono per conoscere e per conservare: provare a confrontarli può aiutare a chiarire qualcosa sia dell'uno che dell'altro.

Il presente articolo intende riflettere su come l’analogia sia intesa e trattata dalla classe di metodi formali di trattamento dell’informazione che si occupano di analizzare il testo scritto. In particolare, si considera come si possano costruire macchine che “comprendono” le analogie. A tal fine ci si avvarrà di esemplificazioni tratte dal _De Civitate Dei_ di Agostino d’Ippona. Le prime indagini compiute su tale corpus, seppure limitato, conducono a riflettere sulla portata teorica e storiografica del trattamento automatico dell’analogia anche nel formulare (...) o avvalorare ipotesi interpretative. _This article aims to reflect on how analogy is understood and treated by the class of formal information processing methods that deal with analysing written text. In particular, we consider how machines that ‘understand’ analogies can be constructed. For this purpose, exemplifications from Augustine of Hippo’s _De Civitate Dei _will be used. The initial investigations carried out on this corpus, albeit limited, lead one to reflect on the theoretical and historiographical significance of the automatic treatment of analogy also in formulating or supporting interpretative hypotheses._. (shrink)

Il saggio prende in esame due punti della teorizzazione di Harry Frankfurt in merito alla moral agency. Il primo è la corretta concettualizzazione del momento della ‘decisione’ all’interno del­­la ca­tena deliberativa. Vengono esaminati tre passaggi critici: a) la base normativa a cui la decisione ri­spon­de; b) la teoria della ‘unificazione della persona’ attraverso la decisione e c) la distinzione fra ‘scelta’ e ‘decisione’. Il secondo punto è l’ambiguità in­sita nel concetto di ‘doveri d’amore’ pro­posto da Frankfurt. A questo pro­posito vengono (...) esaminate: a) la di­stin­zione fra amore ‘attivo’ e ‘passivo’ e b) la mancata tematizzazione della ‘legittimità del­l’a­more’, ovvero del rap­porto fra l’a­more in quanto relazione sociale e i quadri interpretativi del­la cul­tura entro cui si sviluppa.In this paper two aspects of Harry Frankfurt’s theory of moral agency will be examined. First, his conceptualization of the moment of ‘decision’ wi­thin the deliberative chain will be addressed. Three critical junctures will be dis­cussed: a) the normative basis of the actor’s ‘decision’; b) Frankfurt’s view of the ‘unification’ of the person via decision and c) his distinction of ‘choice’ and ‘decision’. The second point addressed is the ambiguity in­herent in Frankfurt’s notion of ‘duties of love’. With regard to this notion, the following points will be discussed: a) the distinction between ‘active’ and ‘passive’ love and b) Frankfurt’s neglect of the dimension of the ‘le­gi­timacy of love’, i.e. of the nexus of love qua social relation and the inter­pre­tive cadres of the culture within which it unfolds. (shrink)

Published in 1977, The tuning of the world by Raymond Murray Schafer, inaugu-rated the soundscape studies, that have shaped much further research, interweav-ing different disciplinary fields, and are based around the concept of sound as a meta-category that both encompasses and transcends music. These studies invite us to reflect on the relationship between human beings and sound environment, on the responsibility of each individual in sharing the soundscape as a common and collective heritage and, more generally, on the ability to (...) exercise hearing as a medium of understanding of the world. (shrink)

An International Fichte Congress was held at the Friedrich-Schiller-Universitat in Jena, September 26 to October 1, 1994, under the auspices of the Internationale Johann-Gottlieb-Fichte-Gesellschaft, in celebration of the 200th anniversary of the Wissenschaftslehre. Participants came from all corners of Eastern and Western Europe, Canada, Japan, and the United States. Well over one hundred papers were read on all aspects of Fichte’s philosophy and Fichte’s heritage. Among the participants from North America some were well known faces from the HSA, such (...) as Daniel Breazeale, George di Giovanni, Tom Rockmore, Jere Surber, and Michael Vater. They all made presentations. An excursion to Weimar proved an enjoyable diversion from the otherwise strict discipline of Fichtean science. (shrink)

In questo saggio si esamina il modo in cui viene concepito il rapporto tra pluralità del bene e universalità della giustizia all'interno del dibattito filosofico politico di matrice liberale dell'ultimo decennio. Vengono ricostruite tre diverse strategie concettuali con cui è stata sviluppata una concezione "situata" della giustizia come imparzialità fra concezioni del bene concorrenti -- la strategia del perfezionismo liberale , quella del proceduralismo e quella della ragione pubblica -- e in particolare il modo in cui dalle diverse ottiche è (...) affrontato il problema della giustificazione politica ovvero della legittimazione. Per ciascuna di queste strategie vengono indicati punti di forza ed elementi di debolezza e viene infine sostenuta la superiorità della strategia rawlsiana della ragione pubblica relativamente alle altre. (shrink)

Language is a collaborative act: To communicate successfully, speakers must generate utterances that are not only semantically valid but also sensitive to the knowledge state of the listener. Such sensitivity could reflect the use of an “embedded listener model,” where speakers choose utterances on the basis of an internal model of the listener's conceptual and linguistic knowledge. In this study, we ask whether parents’ spatial descriptions incorporate an embedded listener model that reflects their children's understanding of spatial relations and spatial (...) terms. Adults described the positions of targets in spatial arrays to their children or to the adult experimenter. Arrays were designed so that targets could not be identified unless spatial relationships within the array were encoded and described. Parents of 3–4-year-old children encoded relationships in ways that were well-matched to their children's level of spatial language. These encodings differed from those of the same relationships in speech to the adult experimenter. In contrast, parents of individuals with severe spatial impairments did not show clear evidence of sensitivity to their children's level of spatial language. The results provide evidence for an embedded listener model in the domain of spatial language and indicate conditions under which the ability to model listener knowledge may be more challenging. (shrink)

IntroductionInternational trade in digitally deliverable services has been developing rapidly in recent years, especially during pandemics. However, the growth rate and scale differ among regions and countries. To promote the growth and bridge the divide of global trade in digitally deliverable services, we provide feasible policy suggestions in this paper.MethodsBased on panel data of 33 countries' digitally deliverable service trade from 2005 to 2020, this study analyzes the development trends and influencing factors of international trade in digital-global service trade.ResultsThe (...) development of digitally deliverable services in developed countries is far ahead, while in emerging economies such as China and India, it is growing at a high speed. Digital infrastructure; human capital; and science, technology, and innovation capacity have a significant impact on the digitally deliverable trade of countries with the level of STI playing the most important influence. Further, heterogeneity analysis shows that human capital and STI capacity are more sensitive to the digitally deliverable trade of middle-income countries than to the impact of high-income countries, and the contribution of population in middle-income countries is more pronounced.ConclusionAs the proportion of digital trade in global trade continues to increase, the role of digital service trade in countries' sustainable development is becoming more prominent. To cope with such opportunities and challenges, countries, especially developing countries, should actively increase digital infrastructure construction, improve talent training, vigorously develop digital technology, and enhance their innovation capacity. (shrink)

What sort of thing is the mind? And how can such a thing at the same time - belong to the natural world, - represent the world, - give rise to our subjective experience, - and ground human knowledge? Content, Consciousness and Perception is an edited collection, comprising eleven new contributions to the philosophy of mind, written by some of the most promising young philosophers in the UK and Ireland. The book is arranged into three parts. Part I, Concepts and (...) Mental Content, which begins with an attack by Hans-Johann Glock on the representational theory of mind, addresses the nature of mental representation. Part II, Consciousness and the Metaphysics of Mind, concerns the prospects for a naturalistic metaphysics of the conscious mind. Finally, Part III, entitled Perception, pursues the project of giving a satisfactory philosophical account of perceptual experience. The book begins with an introductory essay by the editors, which provides an overview of the state of contemporary philosophy of mind, locating the articles to follow within that context. The individual chapters of Content, Consciousness and Perception are professional contributions to their respective areas, of interest to any philosopher of mind. The volume as a whole is ideal for non-specialists and students interested in getting to grips with the state of the art in contemporary philosophy of mind. -/- Praise for the book: 'If you want to know what the next but one generation of philosophers of mind are thinking about now, *Content, Consciousness and Perception * is a terrific place to look. This wide-ranging international collection is relevant to psychologists and cognitive scientists as well as philosophers.' Tim Williamson Wykeham Professor of Logic at Oxford University. (shrink)

The literature on algorithmic fairness has examined exogenous sources of biases such as shortcomings in the data and structural injustices in society. It has also examined internal sources of bias as evidenced by a number of impossibility theorems showing that no algorithm can concurrently satisfy multiple criteria of fairness. This paper contributes to the literature stemming from the impossibility theorems by examining how informational richness affects the accuracy and fairness of predictive algorithms. With the aid of a computer simulation, we (...) show that informational richness is the engine that drives improvements in the performance of a predictive algorithm, in terms of both accuracy and fairness. The centrality of informational richness suggests that classification parity, a popular criterion of algorithmic fairness, should be given relatively little weight. But we caution that the centrality of informational richness should be taken with a grain of salt in light of practical limitations, in particular, the so-called bias-variance trade off. (shrink)

L’introduzione al fascicolo Analogia e medioevo sive vent’anni di analogie presenta il numero 18 di "Doctor Virtualis" e traccia le tappe fondamentali della rivista. Si delineano dapprima alcune linee della storia della rivista e le sue ispirazioni teoriche e storiografiche principali, per poi mettere in luce le ragioni della rilevanza del tema dell’analogia, come oggetto utilizzato e pensato nei secoli medievali e come strumento di ricerca storiografica, e infine si conclude con l’articolazione del fascicolo. The introduction to the issue Analogy (...) and the Middle Ages sive twenty years of analogies presents issue n. 18 of Doctor Virtualis and traces the milestones of the journal. It first sketches some lines of the history of the journal and its main theoretical and historiographical inspirations, then highlights the reasons for the relevance of the theme of analogy, as an object used and thought of in the medieval centuries and as a tool for historiographical research, and finally concludes with the articulation of the issue. (shrink)

ABSTRACT This article aims to compare the national legal systems that regulate biomedical research in an industrialized country (United States) and a developing country (Venezuela). A new international order is emerging in which Europe, Japan and the United States (US) are revising common guidelines and harmonizing standards. In this article, we analyze – as an example – the US system. This system is controlled by a federal agency structured to regulate research funded by the federal government uniformly, either in (...) the US or abroad. In contrast, in Venezuela, a developing country, the creation of a centralized system is a slow process. Different types of ethical committees review research projects using non‐uniform criteria. Consequently, various parallel organizations that conduct biomedical research, such as universities, research institutes and private hospitals have diverse regulations operating at a local level. Thus, the most relevant difference between the Venezuelan and the US systems is the degree of standardization. In the US, the review process is performed by institutional review boards (IRBs), which have a similar organization and maintain relationships with a centralized agency, following standard regulations. Although new proposals for establishing national regulations are currently being considered in Venezuela, the success of these initiatives will depend on promoting governmental efforts to create a more structured centralized system supported by a national regulatory framework. This system will need governmental financial support at all levels. This article proposes an integrated system to regulate research with human participants in Venezuela and other developing countries. (shrink)

I argue that, if drones make waging war easier, the reason why they do so may not be the one commonly assumed within the philosophical debate – namely the promised reduction in casualties on either side – but a more complicated one which has little to do with concern for one’s own soldiers or, for that matter, the enemy; and a lot more to do with the political intricacies of international relations and domestic politics; I use the example of (...) the Obama Administration’s drone policies to illustrate this argument. My point is meant to have wider methodological significance: philosophy can make an important contribution to this and related applied debates; but it is not by artificially – and optimistically – simplifying realities on the ground that philosophers can be of help. (shrink)

Theodicy is often rejected because a suffering person is hardly interested in abstract argu ments—even if these arguments were convincing, they might not change the suffering she is experienc ing. I propose a twofold theodicy. First, Christians are invited to promote positive apologetics—they should show the internal consistency of divine revelation, which recommends that they should alleviate suffering and promote flourishing. Second, Christians should develop negative apologetics and show the untenability of objections to the Christian view of evil and suffering, (...) including the seemingly uncontro versial objection that a world without innocent suffering would be better in terms of justice than the one we live in. My argument is that in both positive and negative apologetics believers should be guided by devotion and commitment to God. The more they love and trust God, and consequently believe what God has revealed, the more they are expected to encourage both flourishing and rational confrontation. (shrink)

In the era of the knowledge economy, the improvement of national innovation systems is playing a significant role in the global entrepreneurship ecosystem. Entrepreneurs are accelerating international intellectual property applications to be competitive. What remains to be explored is the evolution of international intellectual property network in the globe. With the application of social network analysis and intellectual property application database, the global innovation network structure from 2000 to 2019 is explored. Results showed that in the period 2000–2019, (...) the global innovation network has been expanding rapidly from a sparse network to a dense and complex one. Patent application is unevenly distributed in the globe. Countries such as the US, China, and Canada have been the top countries flowing in, while Japan, Korea, EU, and Switzerland have been the main countries flowing out. Global innovation network shows an obvious “core-periphery” pattern. The distribution pattern presents a quadrilateral structure with the four core regions of “US, Japan, EU, and China” as the apex. This analysis contributes to the visualization of the global layout of intellectual property and the evolution trend by analyzing intellectual property application networks. This can provide important experience reference for enterprises to study the global entrepreneurship ecosystem. (shrink)

In experimental economics one can confront a “don’t!”, as in “do not deceive your participants!”, as well as a “do!”, as in “incentivize choice making!”. Neither exists in experimental psychology. Further controversies exist in data collection methods, e.g., play strategy (vector) method in game experiments, and how to guarantee external and internal validity by describing experimental scenarios by field-related vignettes or by abstract, often formal, rules as it is used in decision and game theory. We emphasize that differences between the (...) experimental methodology of the two disciplines are minor rather than substantial and suggest that such differences should be resolved, as much as possible, through empirical research. Rather than focusing on familiar debates, we suggest to substitute the revealed-motive approach in experimental economics by designs whose data not only inform about choice, but also about the reasoning dynamics. (shrink)

Hard Like Water represents a uniquely Canadian, and international, perspective in a field largely dominated by US writers. The accessible book sets up a "core ethic" that helps the reader to link a few, familiar core values: care for life, welfare, honest communication, and civil rights, with business practices. These values are supplemented by five performance maxims: do no harm; solve the problem; enable informed choice; act, learn, improve; and seek the common good. The book is designed to show (...) how ethical and social values are operative in business, both in North America and internationally, and to help both students and business people to understand how ethics can help solve business problems. (shrink)

This article argues that foreign multinational corporations in South Africa cannot evade an ethical choice, how best to exercise their leverage against apartheid? Disinvestment is only one, ambiguous option. MNCs need clear ethical goals and an effective strategy. Both arise from the political economy of the MNC . It involves 3 relationships, between the MNC parent and its subsidiary; the MNC home society and host society; and the MNC home state and host state. That political economy explains the MNC's dependency (...) and modernization effects . Those effects give foreigners some leverage against apartheid; but an effective and ethical MNC strategy is needed . It involves four goals: dismantling apartheid, a mixed economy, full democracy, and a negotiated peace . It suggests a sequence of MNC/home state options from Do Nothing or Divest to More Corporate Activism, Home State Support, and International Sanctions . But victory is not around the corner; rather, we are all condemned to freedom. (shrink)

International criminal law is dedicated to the battle against impunity. However, the concept of impunity lacks clarity. Providing that clarity also reveals challenges for the current state and future prospects of the project of ICL, which this article frames in cosmopolitan terms. The ‘impunity norm’ of ICL is generally presented in a deontic form. It holds that impunity for perpetrators of international crimes is a wrong so profound that states and international bodies have a pro tanto duty (...) to prosecute and punish perpetrators, a duty that cannot be overridden by considerations of cost, including the costs of infringing on the traditionally understood legal sovereignty of states. This deontic reading of the impunity norm is difficult to justify, a fact linked to the waning fortunes of ICL over the past several years. If ICL is to reverse this trend, the impunity norm’s strongly deontic reading should be replaced by a version derived from deliberative principles. (shrink)

We present a stronger variation of state MV-algebras, recently presented by T. Flaminio and F. Montagna, which we call state-morphism MV-algebras. Such structures are MV-algebras with an internal notion, a state-morphism operator. We describe the categorical equivalences of such state MV-algebras with the category of unital Abelian ℓ-groups with a fixed state operator and present their basic properties. In addition, in contrast to state MV-algebras, we are able to describe all subdirectly irreducible state-morphism MV-algebras.

The Cambridge Platonist Henry More was fiercely averse to the Lurianic Kabbalah, with which he became acquainted through the two tomes of the Kabbala denudata. More contributed to the first tome substantially and was highly influential in shaping the reception of this work, edited by Christian Knorr von Rosenroth. He denounced the incompatibility of the Christian religion with Luria's system and in his last contribution, the Fundamenta, he put forward an apagogical argument meant to show the inconsistency of Luria's teaching. (...) The article aims at exploring the nature of More's argument so as to highlight the philosophical essence of his criticism, the intention of which was to emphasize the incompatibility of the Kabbalah with any form of rational speculation. Luria's doctrine appeared to More to be a compromise between materialism and spiritualism, a sort of hybrid theory that was even worse than materialism, given its misleading theistic appearance as well as the lack of internal coherence. This compromise was also morally unacceptable, being symptomatic of weakness of the will. (shrink)

Standard interpretations of Kant’s moral philosophy portray him as affording agents very little, if any, latitude to exercise practical judgment for determining the proper course of action. It is typically thought that Kant holds that because all moral duties are determinable a priori and in advance of particular circumstances this leaves little to no room for agents to exercise practical judgment. In this paper I discuss two senses in which Kant does allow for the practical judgment of agents. The first (...) is an interpretation of Kant’s view of practical judgment developed by Onora O’Neill and others. The second is an underappreciated dimension of practical judgment contained in Kant’s texts. It is to a defense and examination of the importance of the second sense of practical judgment that the majority of this paper is dedicated. (shrink)

The modern republican history of Turkey and its relation with the question of ethnic diversity could be understood via the tension between the processes of system integration and social integration. This article, based on Jürgen Habermas’ conceptual framework, draws the sources of such tension with reference to the Kurdish identity in Turkey since the early republican era. For this purpose, from the 1920s to the 2000s, policies and discourses of system integration aiming at a certain degree of ethnic homogenization to (...) eliminate ‘possible threats’ to territorial integrity and national unity are discussed in detail. While system integration processes reflect an exclusionary and assimilative-securitist logic of state practices regarding the Kurdish question, this article argues that the Kurdish challenge to republicanism and to its system integration logic promises more for the dynamics of social integration. Especially since the 1990s, while processes of system integration are still in force; national, regional and diasporic achievements of Kurdish politics and its call for a democratic transformation of the republic based on decentralist, participatory and multiculturalist values have become much more visible. This new focus on democratic transformation demands more for social integration through internalization of roles as well as through promotion of an active communication between citizens by raising the claims of active participation to social and political spheres as well as by making identity visible in different aspects of socio-cultural life. Degree of social integration and its success vis-à-vis system integration will be decisive in the democratic transformation of Turkey in the future. (shrink)

With the exception of pornography, the morality of popular forms of entertainment has not been studied extensively by philosophers. The present paper aims to start discussion on the moral status of horror films, whose popularity and success has grown steadily since the 1970s. In particular, the author focuses on so-called “slasher” or “gorefest” films, where the narration revolves around the graphic and realistic depiction of a series of murders. The paper’s main thesis is that it is immoral to produce, distribute, (...) and view films of this kind. The reasons are traced back to two facts: 1) living the moral life requires being disposed to react compassionately to the sight of human victimization, and 2) the most violent horror films either overwhelm the spectator or promote a detachment from violence that may interfere with the development and maintenance of the correct reactive attitudes to human victimization. (shrink)

Banks have an important social responsibility to serve the real economy and to maintain financial stability, and they also need to be responsible to borrowers and others. Against the backdrop of the COVID-19 pandemic affecting the global economy and increasing financial risks, it is particularly important for banks to assume social responsibilities. This study theoretically analyzed the outstanding applicability of stakeholder governance theory. Using a two-stage game method, the optimal pressure intensity of the social responsibility stakeholders was calculated, and the (...) dynamic performance of shareholders was deduced. We found that the establishment of the social responsibility stakeholder governance mechanism will prompt the bank to fulfill its social responsibilities; rational social responsibility stakeholders will not lead to poor bank management due to excessive behavior; and shareholders with social responsibility can self-consciously choose the investment projects with lower negative externalities. The conclusions can be summarized as follows: The participation of stakeholder and the establishment of the social responsibility function of the board of directors can help promote a bank's social responsibility performance. This work studied the social responsibility of banks from the new perspective of stakeholder governance, expands the theoretical boundaries, and puts forward relevant suggestions to enhance the application value of this research. (shrink)

Excerpt: In this essay I explore the nature of the necessity of historical development in Nietzsche’s genealogy of Judeo-Christian moral values. I argue that the progression of moral stages in Nietzsche’s study is ordered in such a way that the failure of each stage is logically and structurally necessary, that each failure structures the resultant system or paradigm, but that the historical manifestation of moral paradigms coinciding with predicted or projected theoretical structures is contingent upon a multitude of other historical (...) factors. Therefore, the systematic internal failures of moral stages allow for, but do not cause, successive events. (shrink)

BackgroundData processing of health research databases often requires a Data Protection Impact Assessment to evaluate the severity of the risk and the appropriateness of measures taken to comply with the European Union General Data Protection Regulation. We aimed to define and apply a comprehensive method for the evaluation of privacy, data governance and ethics among research networks involved in the EU Project Bridge Health.MethodsComputerised survey among associated partners of main EU Consortia, using a targeted instrument designed by the principal investigator (...) and progressively refined in collaboration with an international advisory panel. Descriptive measures using the percentage of adoption of privacy, data governance and ethical principles as main endpoints were used for the analysis and interpretation of the results.ResultsA total of 15 centres provided relevant information on the processing of sensitive data from 10 European countries. Major areas of concern were noted for: data linkage, access and accuracy of personal data and anonymisation procedures. A high variability was noted in the application of privacy principles.ConclusionsA comprehensive methodology of Privacy and Ethics Impact and Performance Assessment was successfully applied at international level. The method can help implementing the GDPR and expanding the scope of Data Protection Impact Assessment, so that the public benefit of the secondary use of health data could be well balanced with the respect of personal privacy. (shrink)